Sentence examples for binding is not direct from inspiring English sources

It was previously reported that GABARAP binds to microfilaments (actin) as well as microtubules (β-tubulin); the actin binding is not direct, and it may be mediated by yet unknown proteins (Wang and Olsen, 2000).

However, Two-Hybrid analysis indicated that this binding was not direct (data not shown), suggesting the participation of intermediates in this interaction.

It is possible that, in this case, ubiquitin-binding is not direct, but mediated by the UIM motif bound to cullins.

Our new study shows that at least in SAOS2 cells the influence of sumoylation on the transcriptional activity is due to regulation of the intracellular concentration while the inhibitory effect of the TID that is based on direct binding is not affected.

In fact, no enrichment for TFAP2A was observed in the promoter of these two genes compared with the negative IgG controls suggesting that genes containing only low score or no TFAP2A binding sites are not direct TFAP2A targets and their TFAP2A-dependent modulation is indirect.

The mechanism isn't direct.

We found that EAEC strain 042 has the ability to bind directly and indirectly to integrin α5 β1; direct binding was not mediated by AAF/II fimbriae and indirect binding was mediated by AAF/II and fibronectin.

Direct binding was not demonstrated.

As these experiments take time and may not be possible in a reasonable time frame, the authors should at least acknowledge that direct binding was not tested.

The bindings are not unique to Russia.

However, the weak inhibitor MM has a relatively high efficiency in the bladder binding assay that is not in direct correlation with its affinity compared to HM.