Sentence examples for binding is necessary to from inspiring English sources

First, analysis of in vivo binding is necessary to understand Hox target specificity; the Hox genes encode a set of closely related DNA-binding transcription factors that exhibit clear functional specificity in vivo but show little binding selectivity in vitro (reviewed in [5]).

One hypothesis is that conserved common binding is necessary to provide robustness to regulatory networks during critical stages of early neural development [ 51, 73, 104, 105].

It is therefore possible that other protein protein binding, including ameloblastin amelogenin binding and/or cytokeratin amelogenin binding, is necessary to prevent intracellular amelogenin self-assembly which in turn would lead to secretory failure.

We conclude that Cic1 and Nop15 binding is necessary to maintain or establish a more flexible and open structure in the 5′-end of ITS2, potentially preventing premature formation of the hairpin structure.

Were these constructs the only ones that worked? 1) Figure 1 : Given the modest peak corresponding to Gal4DBD relative to naked DNA, some statistical analysis of the peak height distribution across multiple traces with and without Gal4DBD binding is necessary to understand how confidently the Gal4DBD-bound vs unbound state can be assessed in later experiments.

Specific major comments: 1) Figure 1: Given the modest peak corresponding to Gal4DBD relative to naked DNA, some statistical analysis of the peak height distribution across multiple traces with and without Gal4DBD binding is necessary to understand how confidently the Gal4DBD-bound vs unbound state can be assessed in later experiments.

When the researchers used a chemical trick to simulate ubiquitin binding in the globular section, tests showed that this binding was necessary to activate OTUB1 to inhibit chain formation.

In order to clarify the extent of side-chain flexibility observed upon ligand binding, it is necessary to perform an analysis using a non-redundant dataset of protein cognate ligand pairs as large as possible to increase the statistical significance of the results.

Recently, Stadler et al. [ 19] have shown that low-methylated regions (LMRs) are characterized by the presence of DNA-binding factors and their binding is necessary and sufficient to create LMRs [ 19].

A precise map of binding sites for transcription factors (TFs), core transcriptional machinery, and other DNA-binding proteins is necessary to decode the gene regulatory networks and their contribution to developmental processes and human disease [ 1].

Therefore, we hypothesize that this microtubule/tubulin-binding region is necessary to drive TBCD and tubulins to the procentriolar structures.