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In the absence of the non-informational interaction between RT and the γ-phosphate, the nucleotide binding is hypothesized to be dependent on other, sequence-specific interactions between the incoming nucleotide and the enzyme [5].
Here, cooperative binding is hypothesized to occur through complementarity of DNA conformation at overlapping sites (Panne et al. 2007).
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Reduced SERT binding in depression is hypothesized to reflect decreased expression of SERTs.
Penicillin-binding protein 4 (PBP4) is hypothesized to cleave the terminal D-alanine residue from un-cross-linked peptidoglycan chains [ 19].
Additionally, blocking of nicotine's binding at these receptors is hypothesized to reduce nicotine-induced dopamine release and, consequently, its rewarding/reinforcing effects (antagonist effects) [ 40].
The model displays that our lactonase enzyme has a putative structure of a metalloenzyme that is hypothesized to contain binding sites for 2 zinc atoms where all the residues interacting with the ligand are completely conserved between model and template.
In cases where mutant enzyme is trapped in the ER due to instability or misfolding, specific binding of a small molecule chaperone is hypothesized to stabilize the correctly-folded enzyme, allowing functional material to leave the ER, and decreasing removal of the protein by ER-associated degradation.
The laminin-binding glycan repeat generated by LARGE is hypothesized to be the terminal glycan structure of the α-DG O-mannosyl post-phosphoryl modification.
Upon interacting with SNARE complexes, C2AB adopts a more restricted ensemble of relative C2 domain orientations, which is hypothesized to facilitate simultaneous binding of the two domains to the plasma membrane.
The Escherichia coli phnD gene is hypothesized to code for the periplasmic binding component of a phosphonate uptake system.
The mechanism of gold nanoparticle formation is hypothesized to occur by metal ion binding to the amines present in PAEs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com