Sentence examples for binding is essential to from inspiring English sources

The crystal structure of ligand-free E. coli glutaminyl-tRNA synthetase (GlnRS) at 2.4 Å resolution shows that substrate binding is essential to construction of a catalytically proficient active site.

Thus our data suggests that in order for NOX5 EF1 to adopt an optimal conformation for Ca2+ binding, the structural change on EF2 upon Ca2+ binding is essential to increase its sensitivity.

A kinetics study on VEGF-bevacizumab binding is essential to elucidate the fundamental mechanism of bevacizumab inhibition to the VEGF VEGFR angiogenic switch.

Moreover, they provide evidence that phosphorylation changes induced by cofactor binding are essential to the ability of Gro/TLE1 to inhibit neuronal differentiation.

If ICAM-2/α-actinin binding were essential to the observed ICAM-2-mediated redistribution of actin fibers, expression of ICAM2ΔCD would have no effect on actin fiber distribution and, similar to SK-N-ASpIRESneo cells, actin fibers in SK-N-ASpIRES.ICAM2ΔCD cells would be in a transverse configuration.

In light of the above, isolating the two anticipated counter-acting effects and excluding the stabilizing effect due to tannin-collagen binding is essential in order to design an experiment that provides interpretable results.

Furthermore, they reported that Cdc42 binds to E-cadherin in a GTP-dependent manner and that this binding is essential for Cdc42 to induce the dissolution of adherens junctions [ 52] (Fig.  3a).

These findings suggest that the NF-κB binding site is essential to PP2-mediated rescue of activation of the IL-8 promoter in Thy-1+ MEFs.

340 Co-administration of amino acids, particularly d-lysine, reduces tubular peptide binding and is essential to minimise renal toxicity.

Substitution of each mutant into the system individually results in a significant reduction in activity compared with WT PCNA, consistent with the preceding analysis in which an interaction of PolB1, Fen1 and Lig1 with their respective PCNA-binding sites is essential to the efficiency of maturation.

Therefore, these studies collectively provide robust evidence that PBD-phosphopeptide binding is essential for PLK-1 targeting to recognize the substrate and also regulate the PLK-1.