Sentence examples for binding is essential for from inspiring English sources
One arm binds Est1p, and this binding is essential for telomerase activity in vivo (Seto et al. 2002).
Recent studies show that Ipaf [9] and NALP3 [10] selectively bind ATP/dATP and that nucleotide binding is essential for their function in downstream signaling.
We find that WDR5 binds over a thousand endogenous RNAs and that RNA binding is essential for WDR5 maintenance of ESC pluripotency.
Furthermore, they reported that Cdc42 binds to E-cadherin in a GTP-dependent manner and that this binding is essential for Cdc42 to induce the dissolution of adherens junctions [ 52] (Fig. 3a).
This suggests that while tight target binding is essential for cellular nuclease activity, additional molecular characteristics are required for full efficiency.
Therefore, sensing substrate binding is essential for all types of ABC transporters.
Having demonstrated that UBE2QL1 binds monoubiquitin at its active-site cysteine, we then proceeded to determine if this binding was essential for the growth suppressive function of UBE2QL1 in the soft agar colony formation assay.
Our results are in parallel with the previous finding that a bulky hydrophobic group on Ser3 and Phe4 of ghrelin are necessary for its function and thus indicate that membrane-binding is essential for ghrelin function.
Many drugs from a wide range of therapeutic areas have more than one interacting targets, and the multiple on-target and off-target bindings are essential for their efficacy and side effects.
