In this case, almost trivially, the finding of the binding partners is enabled by a non-specific element encoded in their respective structures – the hydrophobicity of their overall molecular surface.
Ligand-binding site accessibility is enabled by the second extracellular loop, which is held out of the binding cavity by a pair of closely spaced disulfide bridges and a short helical segment within the loop.
VPS34 regulation of multiple pathways is enabled by binding to distinct protein complexes, which allow further spatiotemporal regulation of the different trafficking pathways.
Our observations furthermore suggested that a miRNA inhibits poly(A) tail function during translation initiation [19], possibly by interfering with the formation of an mRNA closed-loop configuration, which is enabled by joint binding of eIF4E and the poly(A -binding protein PA -binding bridging protein eIF4G [43], [44], [45].
Electron transfer is enabled by calmodulin binding in the interface between the two domains.
Further demonstrating a role in DNA damage signaling, γH2AX spreading is enabled by SAFB1 binding to acetylated histones (Altmeyer et al., 2013).
This stable complex is enabled by an extended binding mode of PER2-CBD, which spreads several distinct functional modules over a mostly linear interface.
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Considering the previously determined binding parameters of all substrates, this was enabled by a minimum of 66% turnover in the first polymerization round.
