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Protein binding is dominated by log K OW and correlates with log BCF.
The analysis inferred that binding is dominated by a common molecular recognition mechanism.
For the interaction of receptors of either subtype with the ligand, the binding is dominated by hydrophobic interactions.
Below, we show that thermal stimulation of Sly1 SNARE complex binding is dominated by changes in association rather than dissociation kinetics.
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The binding was dominated by large positive entropic contributions and small but favorable enthalpic contributions.
Salt dependent studies established that the binding was dominated by hydrophobic forces that contributed around 90% of the total standard molar Gibbs energy.
A mean ratio of particle-associated cells equal to 0.3±0.05 was obtained for all samples independently of anti-CD3 density (Fig. 10A), indicating that hybrid-particle binding was dominated by engagement of LFA-1, with neither a positive nor a negative contribution of anti-CD3, at least to cell-particle conjugate formation.
Thus the binding epitope of Fab AbD1556 has the expected size for binding to a rather large protein antigen, the binding site is dominated by the variable region of the heavy chain, particularly by CDR3H (residues Glu99 to Phe107, Kabat numbering 95 to 100C), which lies in the centre of the contact.
A drug lead can be designed at the active core of the protein-ligand interface, where the binding affinity is dominated by a small number of atoms [15] [17].
The cooperative binding mechanism of the IL-13 ligand-receptor interaction is quite different from that of IL-4; here the overall binding affinity is dominated by the interaction of IL-4 with its high-affinity receptor subunit IL-4Rα; the low-affinity interactions do not add significantly to the overall binding free energy (Fig. 1a).
MinoTc binding to PLA2 is dominated by hydrophobic interactions quite different from antibiotic recognition of tetracyclines by proteins or the ribosome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com