Sentence examples for binding is difficult to from inspiring English sources

With other methods, nonspecific binding is difficult to decouple from target-specific binding.

It is possible that VHH T5 10 has higher binding ability to the linker of coating antigens than VHH T1 4 and VHH T3 15 and this nonspecific binding is difficult to inhibit by free TBBPA.

This finding that p63 DNA-sequence motif is an important determinant of in-vivo binding is difficult to reconcile with the fact that p63 motif was not considered a strong predictor in our statistical models.

Our results thus indicate that properties related to binding are difficult to model from the employed representations of structure while catalytic mechanisms seem to associate well with conserved structural similarity (Table S4).

Although being one of the two PET tracers with a pronounced subclass selectivity the quantification of [C]MeNTl binding is difficult due to a near irreversible binding (Smith et al., 1999).

Therefore and given the current knowledge on substrate binding, it is difficult to imagine how these targets fit into the binding site of PKA.

Actually, high binding affinity is difficult to achieve, which may be due to the nature of the protein/protein interaction and the conformational rigidity of the hydrophobic binding groove of MCL-1.

The suggestion of overlapping substrate-binding sites is difficult to reconcile with the formation of a ternary complex but is consistent with a classical (one-site) ping-pong mechanism (Scheme 1; see Experimental Procedures).

It is probably that the affinity interaction between HSA and L-thyroxin occurs via multi-site binding because it is difficult to understand the low binding efficiency if only mono-site binding occurs.

Docking study shows that few amino acids of active site of enzyme are also involved in meropenem binding, hence substrate is difficult to bind on active site properly and does not get hydrolysed.

Unlike nucleic acids, interaction between proteins is not based on well-understood complimentary binding so it is difficult to predict protein-protein interactions, binding partners, substrates, and so forth.