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The balance between extrastriatal SERT and striatal DAT binding is different in CD with and without jerks.
The observation that both Aβ1 40 and β-endorphin are cleaved at unique sites by monomeric rIDE further suggests that substrate binding is different in the monomeric enzyme.
The involvement of actin C-terminal region in TM binding is different in each state.
4. If possible, authors should provide reasons why binding is different in Protein-RNA complexes belongs to different organisms.
Since ΔC-HflX does not interact with 50S (Fig. 3B), it might be that the mode of ribosome binding is different in these homologues.
While TRF1 and TRF2 also recognize telomeric dsDNA via their respective homeobox domains, they only share low sequence similarity with the homeodomain of HOT1 (13 and 5%, respectively, Figure 3A) and DNA binding is different in both cases.
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Because GR expression and binding are different in respect to blood cell type, the variation in cell type percentages in different patients could prohibit reliable evaluation of the role of GR expression and binding with regard to hormone sensitivity [ 12].
Expression patterns of M1 and M1 receptor binding are different in males and females [ 392], which may very well translate into different patterns of synaptic integration in the striatum.
The structure based comparison between the two subfamilies also strongly supports the hypothesis that their substrates are different, because all residues predicted to be involved in EF-2 binding are different in the DUF71-B12 subutmostlyut mostly conserved within this subfamily (Additional file 3: Figure S2 and residues in green in Figure 3C).
Especially, the binding medium identified is different in comparison with Qin Shihuang's terracotta army (259 210 BC).
These proteins form well-defined structures when they bind to other proteins, for example, BRCA2 and TREX-2, but the structure is determined by the binding partner and is different in each complex.
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