Sentence examples for binding is dictated by from inspiring English sources

These symmetrical disubstituted anthraquinones may represent useful leads for the development of human telomerase inhibitors as potential anticancer agents, and the exact mode of intercalative binding is dictated by the positional placement of substituent side chains for effective telomerase inhibition.

Our results on Y83F mutant did not abolish the binding interaction between Gab1 and PTP1B-D181A mutant; it is likely that the binding is dictated by the cooperative tyrosine phosphorylation and a region between 50 280 amino acids in Gab1.

An acidic residue binding to the 2′ and 3′ hydroxyls of the adenine ribose and located downstream of the Gly-rich motif confers NAD(H) specificity, whereas NADP(H) binding is dictated by the presence of a basic residue within the Gly-rich segment.

Although these data do not preclude the existence of interactions outside of the active site and involving regions of Endos distant from the Gwl-phosphorylated site, it is clear that most of the binding is dictated by insertion of the phosphorylated residue into the active site, where it can then be dephosphorylated.

Crystal structures of antagonist bound ERα complexes (raloxifen, tamoxifen) showed that the position of the antagonist ligand in the binding pocket is dictated by the hydrogen bonds to the 3-hydroxyl group corresponding to that of the E2 A-ring and the bulky chain of the ligand that displaces H12 [ 12, 30].

Three zwitterionic polymers tested in this work have clearly different responses to changes in Mg2+ concentration, indicating that such ion-bridged adsorption is strongly dependent on cation-zwitterionic polymer binding affinities and is dictated by the specific chemical structure of the polymer betaine side chain.

The analysis of naproxen binding energetics shows that the location of ligand binding sites in Aβ dimer is dictated by the Aβ amino acid sequence.

Since here the affinities are generally low, selection is dictated by prior binding (or post-translational modification) events.

Moreover, our results clearly indicate that there is indeed a hierarchy in terms of preferential incorporation of proteins into the nanoparticle scaffold, a preference that is dictated by the differential binding affinities displayed by the proteins themselves.

The bending between the two ZFs may be larger than is dictated by the DNA binding state of the ZFs as revealed in the GLI-DNA complex structure [ 7].

Numerous studies indicate that the outcome of CRE-mediated gene expression is dictated by CREB activation and the competitive binding of several dimerized transcription factors, including activators and repressors of gene transcription (Sakamoto et al., 2011).