Sentence examples for binding is critical to from inspiring English sources

In the case of Hoxb9, the protein FBXL10 binds competitively to the structured promoter and the binding is critical to reduce the expression of Hoxb9 [ 30].

Understanding of the interactions essential for ligand target binding is critical to the success of lead discovery and optimization.

Reduced nonspecific binding is critical to prevent analyte loss through nonspecific binding in the flow channels before it arrives at the detection site and also to prevent binding of nonanalyte constituents at the detection site.

Clearly, the affinity of CaM binding is critical to nuclear import efficiency, with even a ~3-fold reduction in binding affinity able to have a significant effect on nuclear accumulation, and in turn likely to be the basis of sex reversal in vivo.

Interestingly, binding of imatinib to the kinase-defective tyrosine-mutant restored the NLS function, suggesting that the kinase domain conformation induced by imatinib-binding is critical to the re-activation of the NLS function.

The knowledge on such descriptors that determine substrate specificity to binding receptors is critical to delineate the drug interaction with BCRP polymorphs and the mechanisms behind their action.

Therefore, identification of sequence variation sites in distinct locations within VAR2CSA, affecting antigenicity and/or binding properties, is critical to the effort of developing an efficient VAR2CSA-based vaccine.

Improving our understanding of the mutational processes in non-coding functional regions like transcription factor binding sites is critical to improve their computational identification.

More importantly, these data show that, although G9a and DNMT3A interaction is maintained in the D905R non-cage ANK mutant, this interaction is not sufficient to ensure proper de novo DNA methylation and a non-redundant function of the non-cage surface of the ANK H3 binding domain is critical to this process.

Indeed, we describe here that TERRAs directly bind the PRC2 complex components EZH2 and SUZ12 and that this binding is critical for PRC2 recruitment to telomeres.

These results suggest that there is no specificity in the ability of the two active site domains of PDI to exchange disulfides with Ero1α, although the substrate-binding domain is critical to allow the exchange to occur.