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Based on the observed binding capacity, the binding molar ratio between HIgG and MEL-A is approximately 1 70, supporting the binding is attributed to the "multivalent effect".
In Gly48Val, loss of SQV binding is attributed to the loss of a hydrogen bond between the carbonyl oxygen of 48 and the amide of SQV.
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In our earlier study the dramatic decrease in the CLA of PDC-109 upon PrC binding was attributed to the dissociation of the polydisperse aggregates of the protein [23].
This also corroborates our earlier finding [ 59, 60, 63] that phosphorylation of T18 does not diminish helicity of TA to the extent that it should disrupt binding to MDM2; indeed the disruption of binding was attributed to the development of electrostatic repulsions between phosphorylated T18 and the MDM2 surface and our current results are in accord with our earlier hypothesis [ 17].
Density functional theory calculations reveal that the experimentally observed strong CNT-Ti binding interface is attributed to strong chemisorption interactions of Ti atoms on CNT surfaces, albeit moderated by the weakening effect of the oxide layer.
The other one shifting by ~2 eV to a lower binding energy is attributed to TiOx suboxides on account of the TiO-terminated BTO initial surface [14].
Mutational studies have also shown that the direct Tat:7SK RNA interaction does not require Tat's pTEFb-binding capacity, but is solely dependent on Tat's RNA-binding activity, which is attributed to its RNA binding-domain (RBD, G48-R57 14. G48-R57 14
This high binding energy peak is attributed to the positively charged nitrogen (N+), indicating that the polyaniline/gold nanocomposite was in the doped state (the emeraldine salt form).
This design was chosen to preserve the Wnt-ligand binding region that is attributed to the CRD, a characteristic feature of Frizzled receptors [16].
The other overlapping peak at a binding energy of 530.8 is attributed to surface adsorbed oxygen (Oβ).
These studies revealed that most of the binding affinity (∼50%) is attributed to the phosphate moiety of the pTyr residue while residues in positions from −2 to +4, relative to the phosphotyrosine, modulate binding specificity.
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