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An interesting possibility is that persistent binding is attributable to the elevated C/EBPβ concentrations in differentiating cells, however the effects of DMI-induced post-translational modification of C/EBPβ on homodimer binding cannot be excluded.
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The distance changes between specific loci in IC and EC segments in response to ion and/or ligand binding are attributable to isomerization of these transporters between different functional states (i.e., outward-facing, inward-facing, and occluded).
These highly positively charged dyes typically exhibit poor binding selectivity between dsDNA and ssDNA because a large portion of their DNA binding affinity is attributable to electrostatic interaction, for which ssDNA is also effective.
Since Ubp3 physically interacts with the known RBP, Bre5, it is possible that the apparent RNA-binding activity of Ubp3 is attributable to Bre5.
However, the inferior potency of neonicotinoids at the vertebrate nAChR model is attributable to multiple binding conformations conflicting in the agonist-binding pocket.
The inhibition of MUL hydrolysis is attributable to the binding of cellobiose to the product sites (+1/+2) of TrCel7A [ 52].
A second mechanism by which TD-1 alters the oxygen affinity of hemoglobin is attributable to the binding of the six MUs in the central water cavity.
Dihydrotetrabenazine binding is a good marker of nigrostriatal dopaminergic denervation, as over 95% of the striatal signal is attributable to dopaminergic vesicular binding and shows excellent correlation with tyrosine hydroxylase-positive neuron density in the substantia nigra pars compacta (Vander Borght et al., 1995).
The relatively long duration of action of zoledronic acid is attributable to its high binding affinity for bone mineral.
This difference is attributable to powerful protein-binding sites for NADH; the redox buffer capacity of these titratable NADH-binding sites provides a cytosolic set point at about 1 μ M free NADH, despite much higher total cytosolic NADH (pNADH=6).
Thus, any differences in reporter expression between the wild-type and mutant enhancer constructs is attributable to the Fkh-binding site mutations and not to local positional effects.
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