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Exact(3)
Therefore, one can frequently find the hypothesis that within a congeneric series of closely related ligand analogs the entropic contribution to binding is assumed to be equivalent.
Oxygen-myoglobin binding is assumed to be maintained in equilibrium in the tissue model.
Ligand binding is assumed to unidirectionally influence the phosphorylation of the two regarded intracellular domains [ 36, 28].
Similar(56)
The profiles characterizing DNA protein binding are assumed to be defined throughout the sites.
Ligand-TF and TF-operator binding are assumed to be fast processes and set to quasi steady state.
In contrast, nitrogenous base binding was assumed to be thermodynamically unfavorable, with a respective equilibrium constant = k bind / k diss << 1.
Bmax and Kd values of [H]Paroxetine binding were assumed to represent SERT density and ligand binding affinity, respectively, whereas Vmax and Km values of [H]Serotonin uptake were taken as estimates of SERT rate and affinity, respectively.
Known sites of condensin binding are assumed to coalesce into one complex temporarily if they come within 40 nm of each other, the capture radius consistent with the physical dimension of condensin.
The influence of protein binding on disposition of chemicals has only been investigated in SBSP models using the explicit relationship described by eq 14. (2110) As the first approximation, protein binding was assumed to be dependent on lipophilicity, according to eq 4 in section.
Replacement of water from the uncomplexed binding pocket is assumed to be entropically favorable.
Although the binding rate is assumed to be proportional to the agonist concentration, the rates of the conformational changes are concentration independent.
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