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It is the monomer that binds to DNA and this binding is an important step in transcriptional activation at the majority of eukaryotic promoters.
Detailed knowledge of shikimate binding is an important step in the design of inhibitors of SK, which have potential as novel anti-tuberculosis agents.
Tethering of platelets to the endothelial layer of the vessel wall via GPIb/vWF binding is an important initiator of thrombus formation under high shear conditions such as in the arterial system [3], [6], [8], [27].
It has been suggested that this imbalanced co-factor binding is an important determinant of IBMPFD pathology, possibly by trapping functioning VCP in unproductive co-factor complexes.
We believe that this MOF-independent MSL2 binding is an important piece of information for the epigenetics community, which we would like to keep in the manuscript.
Our in vitro and in vivo data characterizing the WDR5 F266A mutant suggest that RNA binding is an important aspect of WDR5's cellular function, however currently only two RNAs have been identified as WDR5 partners.
Similar(51)
The hydrophobic particles also appear to retain the most salivary proteins after the two SDS elutions, which may indicate that this hydrophobic binding is a more important interaction in the oral cavity with regards to pellicle formation.
Not knowing which 3-D shape of a molecule is important for binding is an inherent limitation of all 3-D similarity approaches that require 3-D conformer models.
Synergistic binding of multiple transcription factors to certain combinations of binding sites is an important mechanism of achieving highly specific regulation of genes in particular cellular conditions.
Protein affinity maturation using molecular evolution techniques to produce high-affinity binding proteins is an important step in the generation of reagents for cancer diagnosis and treatment.
The stress load-sharing between the particulate additive and the binding matrix is an important factor in design and development of these composite materials.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com