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The binding is also demonstrated to shift the monomer-fibril equilibrium in favor of dissociation.
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This cell surface binding was also demonstrated dose dependently by flow cytometry.
A role for PE in PA-effector binding was also demonstrated by Young et al. [ 28] for binding of a transcriptional repressor in yeast, Opi1, which will be discussed in more detail in the next section.
Weak binding affinity was also demonstrated for P6CON, a high affinity binding site for Pax6 [52], the human homolog of Eyeless (Fig. 5B, compare lanes 1 and 5, and Fig. 5C, left panel for quantitative comparison).
In addition to this [H]-VUF11211 based profiling, for proof of principle, the ability of metabolites to displace the natural orthosterically binding chemokine was also demonstrated using a I-CXCL10-based radioligand binding assay.
Detection of single biomolecular binding events was also demonstrated using nanoparticles as labels.
Highly efficient and specific displacements of both ligands from their endogenous mitochondrial binding sites were also demonstrated (data not shown).
It is also demonstrating demand.
The inhibitory effects of thiacremonone on the NF-κB DNA-binding activities were also demonstrated in macrophages stimulated by TNF-α, IFN-γ, and IL-1α.
The impact of LL-37 binding to polysaccharides was also demonstrated in an animal model of Pseudomonas sinusitis biofilm, where a high concentration of LL-37 derived peptide was shown to eradicate Pseudomonas biofilms and decrease bacterial viability [21].
A potent role for the active form of lovastatin in increasing trastuzumab binding to cancer cells was also demonstrated via competitive radioligand saturation-binding assays (Fig. 2h and Supplementary Fig. 4c).
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