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In line with previous reports, we conclude that direct AR binding is a significant but minor determinant of overall expression changes.
The strong association between binding and increased expression indicates that STAT3 binding is a significant contributor to the gene expression pattern in GCB and ABC DLBCL.
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Onto-Express analyses depicted in Figure 4 shows that transcription factor binding is a highly significant component in our microarray data.
A more in-depth look at the mode of encounter for these residues shows that for both D54 and E65 the main cause for the reduction in total binding time is a significant reduction in secondary hits.
The successful crystallography of hormone-binding GPCRs is a significant breakthrough in GPCR research that has required the recombinant generation of high levels of GPCR protein, enhancing their stability (e.g., using stabilizing ligands) and structural modifications to encourage crystal formation.
More recently, there was the discovery that the RNA/DNA binding protein TDP-43 (transactive response DNA binding protein 43 kDa) is a significant component of ubiquitin-positive intraneuronal inclusions in certain cases of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) (Neumann et al., 2006).
It was also hypothesized that mutations of Glu155 and Asp156 in TEM8 Part 4 would significantly affect PA binding affinity because there is a significant position shift in the host loop between TEM8 and CMG2.
5) In Figure 4 figure supplement 1A 1 there is a significant binding of IRESs to the 40S ribosome in RRL.
There might be a mistake in measuring band intensities/calculations. 4) Why does the GGC mutant binds 80S in Figure 4A (lane 26), but not in Figure 4 figure supplement 1A 1? 5) In Figure 4 figure supplement 1A 1 there is a significant binding of IRESs to the 40S ribosome in RRL.
The measured values are shown in Table 1 and Figure 2. The KD of full length topoisomerase IIβ was found to 72.9 nM which while lower than that of full length topoisomerase IIα at 189 nM (implying stronger binding), is not a significant difference, with a p value of 0.0542 by Student's t-test.
For intentional binding there was a significant main effect of 'preceding trial run', F 5, 95), 2.37, p = .045, ν partial 2 =. 11.
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