Sentence examples for binding is a requirement from inspiring English sources
Because substrate binding is a requirement for efficient cullin neddylation [16], [23], full length Cul1 also exhibits markedly reduced conjugation with Nedd8.
In particular, it has been pointed out that, at least in muscle, Ca2+ binding is an absolute requirement for PK activity [ 15].
Since binding is a precursor to synthesis, the same nucleotide requirement holds for pol V Mut-catalyzed primer extension.
Therefore, instead of classic SH3 domain binding, there is a requirement for the C-terminal region for the binding to RasGRP1 that includes residues that comprise an SH3 domain.
A key requirement for induced-fit binding is an initial 'loose' contact between the two molecules, followed by structural adaptations to form a higheraffinity complex.
This suggests that the presence of lateral interactions between FtsZ polymers stimulates the binding of ZapA and most likely is a requirement for the interaction of ZapA with FtsZ.
Recent studies with Vps4 have shown that nucleotide-induced asymmetry is a requirement for substrate binding to the pore loops and that recruitment to the protein lattice via MIT domains also relieves autoinhibition and primes the AAA ATPase cassettes for substrate binding.
Conversely, others have suggested that there is a requirement for Dsh binding to Fz for canonical signaling (Umbhauer et al. 2000; Wong et al. 2003; Cong et al. 2004; Wu et al. 2008), and together with other data this has led to the suggestion of a common mode of Fz receptor activation (Povelones et al. 2005).
Our results establish that metal binding is not a requirement for loop organization and further that zinc binding may, in part, proceed through a conformational selection mechanism whereby zinc binds to excited state conformers that contain the transiently formed helix in the electrostatic loop.
