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Results suggest that the binding is a low energy physio-sorption, likely associated to a partial displacement or specific arrangement of the citrate capping on the gold core.
One factor that causes significant variation in PHT plasma protein binding is a low plasma albumin level (hypoalbuminemia), leading to an increased free PHT fraction, although other factors such as uremia or drug-drug interactions (e.g., inhibition of phenytoin metabolism by valproic acid) can also alter the free fraction of PHT [ 14, 15].
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Nestargel (Swedish Nestlé AB, Findus®, Bjuv, Sweden), usually used as a milk thickener for infants because of its water-binding capacity, is a low calorie product containing soluble, viscous dietary fibres (96.5%) provided as seed flour of locust bean gum (St. John's bread), and calciumlactate (3.5%).
This graph illustrates clearly that the binding site is a low-affinity binding site as the curve does not show saturation even at high ATP concentrations.
Retinol binding protein (RBP) is a low molecular weight plasma protein (21 kD) which is secreted by the liver and transports vitamin A in the blood.
Heart-type fatty acid-binding protein (H-FABP) is a low molecular weight protein in the cytosol of cardiomyocytes, and is rapidly released into the circulation from damaged myocardial tissue [6].
In human versus cattle comparison two single non-overlapping binding sites were found, but this is a low score in comparison with the number of conserved TFBS found in other Early genes.
A second binding cavity, which is a low-affinity site for histamine in one of the HBPs, is located at the end of the barrel that is closed off in other lipocalins.
Such initial non-binding commitment might be a low barrier for actors to get involved.
In contrast, Mec1p telomere binding is extremely low, even in tel1 Δ cells where it is required for telomere elongation.
Protein binding is quite low at approximately 40%40%50%50% of the drug is associated with red blood cells.
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