If transcription factor binding is a general feature of MER20s, particularly by FOXO1A, HoxA-11, CEBPβ and p300, then MER20 derived regulatory elements may be orchestrators of ESC differentiation.
Such binding is a general characteristic of attention (Treisman & Gelade, 1980), and recent work has shown that a robust hallmark of attention (the N2PC) is specifically associated with the combined localization and identification of targets in a visual search task (Hyun, Woodman, Vogel, Hollingworth, & Luck, 2009) but unassociated with mere target detection.
Both in vivo and in vitro studies of Dscam have revealed that highly specific homophilic binding, which may arise from high binding affinities, is a general property of these cell surface proteins, and that this property is crucial for its proper physiological function [ 1, 4, 20].
The assay method is based on a fluorophore that binds the anesthetic cavity on apoferritin, shows a large increase in fluorescence on binding, and is a general, GABAergic anesthetic itself [3].
To investigate if this regulatory switch is restricted to aldolases, or if lysine acetylation of substrate binding sites is a general mechanism to inhibit enzymes in the glycogen synthesis pathway, we tested the function of an equivalent lysine acetylation site we identified on glycerol-3-phosphate dehydrogenase (GPD1).
TATA-binding protein is a general transcription factor that binds to certain sequences of DNA bases found within promoters.
Helicase_C is observed to execute ATP binding (GO 0005524) and nucleic acid binding (GO 0003676), which is a general term for DNA binding (GO 0003677).
On the other hand, the inhibition of wt PrP conversion reactions by synthetic peptides overlapping the β2-α2 loop suggests that the acquisition of binding properties by this loop is a general step in the prion formation and validates its behavior as pharmacological target [45].
RNA was isolated from each fraction and analyzed for expression of GAPDH by reverse-transcription and PCR and, in parallel studies, the proteins in each fraction were analyzed by Western blot for cytolasmic poly(A -binding protein 1 (PA -bindingh is a general translation factor for mRNA, and for B5.
To determine if 14-3-3 14-3-3 14-3-3cell cycle regulatory proteins is a general characteristic of the G2,M phase of the cell cycle or specific to Vpr arrested cells, we examined synchronized Jurkat cells using DNA polymerase inhibition by aphidicolin [ 47].
Some proteins that bind ATP do so in a characteristic protein fold known as the Rossmann fold, which is a general nucleotide-binding structural domain that can also bind the coenzyme NAD.
