Sentence examples for binding intervals that are from inspiring English sources

List of target genes annotated to binding intervals that are uniquely bound by SoxN and conserved between D. melanogaster and D. simulans.

List of target genes annotated to binding intervals that are uniquely bound by Dichaete and conserved between D. melanogaster and D. simulans.

List of target genes annotated to binding intervals that are commonly bound by Dichaete and SoxN as well as conserved between D. melanogaster and D. simulans.

In D. melanogaster, only 53 S2 cell and 105 OSC compensatory CRMs contain Dichaete binding intervals that are also compensatory relative to D. yakuba, while in D. yakuba, only 90 S2 and 157 OSC compensatory CRMs contain Dichaete binding intervals that are also compensatory relative to D. melanogaster.

Previous comparative ChIP-seq studies of TF binding in Drosophila have found that overall nucleotide conservation is not significantly elevated in binding intervals that are conserved between species [ 76, 77].

(D) SoxN-Dam binding intervals that are annotated to a SoxN direct target gene are more likely to show two-way conservation and are less likely to be unique to D. melanogaster than those that are not (p = 3.4e-5).

This mode of regulatory evolution appears to be important for Dichaete, as we found that in all pairwise comparisons, the majority of binding intervals that were not positionally conserved in one species had at least one binding interval present at a different position within the same locus in the other species.

Focusing on Dichaete binding intervals, we compared intervals that are bound in all four species, including D. pseudoobscura, to those that are unique to D. melanogaster.

While Dichaete and SoxN commonly bind the majority of conserved binding intervals, we also identified intervals that are uniquely bound by each TF in both species.

Not only were there a large number of binding intervals commonly bound in both species, intervals that are commonly bound in either species are significantly more likely to be conserved than intervals bound uniquely by one Sox protein.

These perfectly conserved motifs make up approximately 15% of Sox motifs in intervals that show four-way binding conservation but only 12% of Sox motifs in intervals that are uniquely bound in D. melanogaster.