Sentence examples for binding interior from inspiring English sources

The members of the lipocalin family contain a common tertiary structure with an eight-stranded β-barrel surrounding a cup-shaped ligand binding interior, covered with hydrophobic amino acid residues.

And adding more importins to the dots' coating shortened the transit time, suggesting that importins make incoming cargo more soluble within the NPC rather than binding to interior walls.

So, the coordinated water molecules appear to play as precursors of K+ binding in the interior traversing process.

Taxanes cause apoptosis by binding to the interior surface of the beta-tubulin subunit of microtubules and disrupting cell architecture.

Irvine says that his lab is also interested in harnessing this cell-penetrating mechanism as a way of delivering drugs to the cell's interior, by binding them to the surface coating material.

In principle, this solution could be at either q* = q m or q* = q M. From the condition L q ′ = 0, and from the hypotheses on the functions of the problem, it holds that π′(q*) < 0, and so the solution is given by q* = q M. Another interesting feature of this model is that it generates a change in the solution regime when the solution passes from interior to binding or vice versa.

Figure 4B shows that both stapled botulinum products efficiently entered the neuronal interior combining binding and translocation functions of the neurotoxin.

Essentially no crosslinks were obtained on the convex side of Spy despite the abundance of lysines on the convex side, providing evidence that peptide binding occurs on the interior concave surface of the Spy homodimer.

A speculative function for Lys126 may therefore be to form a salt bridge with Glu400 in the outward open conformation, facilitating the closer packing of helices H4 and H10 and sealing the binding site to the interior of the cell in the outward facing state.

Rewiring water networks in protein interiors impacts binding affinity, catalysis and the thermodynamic signature of biochemical processes through dynamic mechanisms, and thus has great potential to enhance binding specificity, accelerate catalysis and provide new reaction mechanisms and chemistry, that were not yet explored in nature.

Structural comparison of the inward facing PepTSt structure with the occluded conformation of PepTSo supports our previous model where we proposed the C-terminal domain is more dynamic, with helices H10 and H11 facilitating opening of the central peptide-binding site to the interior of the cell during transport.