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Our hypothesis is that, if HBGAs are the viral receptors necessary for norovirus infection and spread, their binding interfaces should be under a selection pressure in the evolution of noroviruses.
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To give you an example, we've been discussing the first acquisition for interfaces should be the Graphical User Interface, or G.U.I. -- the Xerox Star 1981.
Interfaces should be as flat as possible.
Such a dynamic property of the interface should be general to all polymerase DNA binding complexes to ensure the biological function of DNA synthesis.
(b) HSS: Cx interface should be enhanced.
Furthermore, a single user interface should be avoided because each end user requires a different user interface.
We further note that our definition of function as binding that leads to specific subsequent events explains why interface design is so difficult: the binding should be such that it would elicit an allosteric transition culminating with (far away) binding sites that have "correct" conformations.
Its binding site should be well characterized.
"Shall" implies legally binding; the verb should be "should".
To determine the functional significance of Spc105p binding to MTs it will be necessary introduce specific disrupting mutations into the putative MT-binding interface, a task that should be aided by ongoing crystallographic studies.
Thus, the interface of TSP should be adapted to IP.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com