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This surface harbors the binding interfaces for many proteins involved in the process of transcription initiation.
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In order to interfere with such complexes, we deleted the binding interfaces for Abp1 and Cdc42 on N-WASP.
Consistently, crystal structures of B3 CME complexes show that B3FUS3, B3LEC2 and B3VAL1 employ a nearly identical binding interface for CME.
In addition to the dileucine-motif binding interface, AP-2 α–σ2 hemicomplex has an additional binding interface for Nef.
(C ) View of the Doc binding interface for each mode from the perspective of Coh.
These ligand binding sites correlate with known protein-protein binding interfaces required for oligomerization.
Many CHD-causing NKX2-5 mutareons are located within the conserved HD, which serves as both a sequence-specific DNA-binding domain and protein-binding interface for interactions with other kernel TFs (Elliott et al., 2010).
Speech input will become a natural interface for many wearable applications and intelligent devices.
We suggest these binding interfaces are critical for setting the αβ-tubulin configuration during biogenesis.
It is well accepted that a few key residues at binding interfaces (binding hot spots) are responsible for contributing most to the free energy of binding.
This removes the barrier the standard command line interfaces pose for many immunologists11.
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