Sentence examples for binding interface within the from inspiring English sources
It is not clear how the two domains cooperate to form a complex with the RRE, but a theoretical structural model of the ERev protein places the ARMs in close proximity within the three-dimensional structure, suggesting they could form a single RNA binding interface within the Rev-RRE complex [27] (Lee and Ihm, personal communication).
To gain further insight into this antibiotic resistance mechanism, we sought to identify residues important for the interaction of FusB with EF-G and thereby delineate the binding interface within the FusB EF-G complex.
These results suggest that the heavy chain-binding interface lies within the highly conserved G domain and not in the C-terminal domain.
Conservation of the CysM−CysO binding interface is maintained within the Mycobacterium genus but shows greater variation, especially in CysM, for other species.
The findings of the conservation of HBGA-binding interfaces within genogroups can greatly facilitate the design and development of therapeutics against noroviruses.
The high conservation of HBGA-binding interfaces within genogroups may also help in the development of new strategies to control and prevent norovirus infection.
A secondary binding interface consists of the β4−α2 region.
Thus, mutations at residues near the binding interface can also abolish the function of the binding interface.
The results revealed that the residues within the binding interface contribute differently to affinity and to the conformational structuring that leads to co-receptor binding.
Mapping the gp120 b12 binding interface identified amino acid polymorphisms within the C2, C3, C4 and V5 regions of gp120 associated with augmented b12 binding, and importantly, identified residues in the b12-exclusive binding domain of gp120 that are important for b12 neutralization resistance.
The Norrin Fz4CRD binding interface is conserved between the complex structures.
