Sentence examples for binding interface it is from inspiring English sources

While SH3-induced dimerization of the DH domain would obscure the Cdc42 binding interface, it is unlikely that this is the mechanism by which intersectin-1L GEF activity is autoinhibited.

In the context of protein interaction networks and the nature of the binding interface, it is possible to predict when subfunctionalization might be possible.

Because the single intrinsic W325 is located on the finger subdomain and is far from the binding interface, it was used as a control site.

However, a protein with many transient interaction partners may transiently interact with its different partners through the same binding interface (though it is possible that the protein may form a transient complex with its partners through multiple distinct binding interfaces), thus the PPID of the protein may not well reflect the proportion of its interface residues [ 22].

Relatedly, how easily does orthologous neofunctionalization occur and how dependent upon protein fold and binding interface size is it?

Interestingly, 2 residues shown through crystallography to be contacts in the binding interface were also identified as being under diversifying selection (D48 and I115 in CPXV-BR, E48 and L115 in ECTV).

Identification of binding interface region is especially useful for cellular pathways analysis and drug design.

Moreover, it was suggested that ANTXR2 residue H121 might be a key component of this triggering mechanism since this residue is located at the PA domain 2 binding interface and is conserved in ANTXR1 [18], [18].

However, the binding interface was more likely to be weakened by the mutation, and the heteromer might be prone to dissociate under extreme conditions as evidenced by a significant decrease in the stability (Fig. 3).

This secondary binding interface is only specific for Nef, and has never been reported with other natural AP-2 cargo proteins [ 29].

However, the AlkA DNA binding interface is not positively charged, and few electrostatic DNA contacts are observed in crystal structures of AlkA·DNA complexes.