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(C ) View of the Doc binding interface for each mode from the perspective of Coh.
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Consistently, crystal structures of B3 CME complexes show that B3FUS3, B3LEC2 and B3VAL1 employ a nearly identical binding interface for CME.
We identified small molecule inhibitors specific to SCF-Skp2 activity using in silico screens targeted to the binding interface for p27.
These domains form an extended surface adjacent to the active site suggestive of a binding interface for interaction with a specific substrate.
Furthermore, these results indicate that the overall tertiary and/or quaternary structure of CEACAM1 on the cell surface is critical to provide a binding interface for non-opaque meningococci.
This suggests that rather than simply providing an E2 binding interface for Cullin proteins, the Roc proteins are structurally distinct and specific RING domains play an important role in determining overall CDL function during development.
Indeed, both the in vitro reconstitution of actin polymerization and the reconstitution of Abp1/N-WASP complexes at membranes in vivo clearly revealed that the Abp1 SH3 domain, i.e. the binding interface for N-WASP, acts in concert with the small Rho-type GTPase Cdc42 to regulate N-WASP-stimulated Arp2/3 complex-dependent actin polymerization.
In addition to the dileucine-motif binding interface, AP-2 α–σ2 hemicomplex has an additional binding interface for Nef.
Overall, the Mediator has an extended shape upon interacting with the Cdk8 kinase module, which provides a large binding interface for the kinase module.
Since Ndel1 and Lis1 also act on MTs we hypothesized that the C-terminus of p600 served as a binding interface for Ndel1 and/or Lis1.
Analysis of the docking poses of protein-protein complexes reveals that the CRD of galectin-3 is the most probable binding interface for integrin molecule.
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