Sentence examples for binding interface can be from inspiring English sources
While most residues in the direct SCF/c-Kit binding interface can be identified from the existing crystal structure of the complex, other residues that affect binding through protein unfolding, intermolecular interactions, allosteric or long-distance electrostatic effects cannot be directly inferred.
In a classical case, dynamic properties of a binding interface can be tuned by a flexible regulatory region.
Here we show that the R97 binding interface can be of importance for the functioning of IRAK-M depending on the cell type, stimulus and readout.
For example, the interaction between p53 and MDM2, which involves a comparatively small binding interface, can be blocked by several chemical classes of small molecules, some of which have progressed to the clinical investigation stage. 2 Similarly, small-molecule BH3 domain mimetics block the interaction of anti-apoptotic Bcl2 family members with BH3-domain-containing pro-apoptotic proteins.
SP and ME interactions and the corresponding binding interfaces can be directly studied by overlaying high-quality protein interaction data with known three-dimensional structures of protein complexes.
A high quality combinatorial library specifically customized to a given binding-interface can be rapidly designed by high-throughput mutational scanning of single substitution libraries.
The opening of the nucleotide binding sites at the dimeric interface can be clearly demonstrated by the distance between the two highly conserved ATP binding motifs, one from each NBD monomer.
Such ion permeation at the sensing interface can be advantageous for recognition of DNA hybridization through modulation of the charge-transfer resistance due to DNA binding events.
We furthermore address how language-neutral interfaces can be extended with import bindings to recover the desired programming idioms.
