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In addition, the concave surface of TON1937 is proposed to be its potential binding interface based on this structural comparison and its surface properties.
Such ambiguity mandates that any model of the arrestin rhodopsin binding interface based on presently available data will inherently be suggestive at best.
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Arg112 and Lys145 may be located in the HS-binding interface based on their interaction with sulfate ions and their mutation to histidine or glutamine could have an effect of lowering affinity for HS.
Without exception, the affected residues in the Ts– strains lie within the dimerization interface encompassing the GTP-binding pocket (the G interface), based on the locations of the equivalent (and highly conserved) residues in human septins.
Herein, we show that tri-peptides appear to be good candidates for the design of inhibitors/binders of the Elk-1 dimer interface, based on size and binding specificity; di-peptides, on the other hand, appeared to behave as generic protein surface binders.
Lim, S. et al. Transparent and stretchable interactive human machine interface based on patterned graphene heterostructures.
Fig. 2 Network slicing of air interface, based on [31].
BioGuide offers a graphical interface based on oriented graphs to query DBs (e.g. Entrez).
We constructed a protein interaction network of the podocyte-GBM interface based on expert knowledge.
The reagents were selected through a web interface based on Pipeline Pilot (Accelrys Software Inc).
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CEO of Professional Science Editing for Scientists @ prosciediting.com