Sentence examples for binding interactions that were from inspiring English sources

Docking results of compounds 2 7 with BChE provided valuable information about the nature of the binding interactions that were satisfactorily correlated with the experimental studies.

By the end of the simulation, the peptide-free DR1 has satisfied all of the N-terminal binding interactions that were lost by initial removal of the peptide in a manner consistent with the original bonds made by the peptide-DR1 interaction.

The Unc45b/Hsp90 complex specifically binds the unfolded myosin motor domain but not native myosin, binding interactions that are characteristic of a chaperone complex.

In conclusion, we have demonstrated that FINDSITEcomb is an automated, robust and rapid methodology that can identify novel protein-ligand binding interactions that are often in the nM range or better, and which, in combination with appropriate mechanistic studies and biological activity assays can be a promising tool for lead identification/drug discovery.

This phenomenon has been previously described, and it has been attributed to nonspecific IHF binding interactions that are superimposed on the specific binding event.

Other categories of genes may represent lineage-specific innovations or tissue-specific binding interactions that are not present in the cell culture system.

Further molecular modeling and testing with additional compound chemotypes might help illuminate the particular binding interactions that are involved in compound specificities.

For binding, there is a greater conundrum in that while the real biological decoys are not known, a random contacts model has the potential to be too restrictive in selecting against binding interactions that are not biologically deleterious.

In general, residues that photo-cross-link are likely to be involved in binding interactions that are at the periphery of the protein protein binding interface and are therefore weaker than those in the core hot spot.

Here, we seek to identify ligand-binding interactions that are generally associated with Cys-loop receptors, including the frequently observed cation−π interaction.

Whenever time-resolved data were available, we restricted our attention to binding, concentrations or interactions that were identified to be circadian at the appropriate statistical level (see details above).