Sentence examples for binding interactions observed in from inspiring English sources

Studies of linker strand-binding adenine isosteres identified SAR trends in potency and selectivity that were consistent with binding interactions observed in structures of the inhibitors bound to AKT1 and to the counter-screening target PKA.

Four figures depicting product inhibition and product binding interactions observed in complexes I, II, and III.

The efficacy of a compound to activate LasR was directly correlated with its ability to maintain the binding interactions observed in the LasRLBD/C12-HSL binary complex.

Importantly, binding of IHF to the I1 duplex is observed at concentrations well beyond that required to fully saturate the specific binding interaction observed in the EMS study [<50 nM].

Given that BAK1 has no BL-binding activity, their interactions observed in the structure should be dependent on binding of BL to BRI1LRR.

However, since our transactivation assays do not indicate direct binding, the TF-TPS promoter interactions observed in the ATTAs, could take place through an additional protein.

MD simulations of the mutant systems established the pattern of stable polar interactions observed in high-affinity binding BH3 peptides.

Mutagenesis studies, biochemical assays and electrophysiological recordings directly correlated the interactions observed in the co-crystal structure to binding affinity at AChBP and different nAChR subtypes.

It is very common that interactions observed in experimentally derived structures may or may not have energetic contribution to binding and function.

In addition to these polar interactions observed in the structure, the N- and C-terminal extensions of ATRXDBM may also contribute to binding with DAXXDHB through electrostatic interactions.

This concern arises from the apparent tight-binding of nucleotide in the crystal and relatively weak interaction observed in the e-phys recordings.