Sentence examples for binding interactions in the from inspiring English sources

The X-ray crystal structures of 11c and 25 complexed with PTP1B were solved and revealed nearly identical binding interactions in the active site.

The identification of the binding interactions in the EGFR/ligands and the ABL/ligands complexes can facilitate the structure-based design of new tyrosine kinase inhibitors.

Samples that tested positive in the screening assay were further evaluated in a confirmatory assay, which used excess unlabeled drug in a competitive binding format to demonstrate the specificity of the binding interactions in the antibody-labeled drug complex.

To validate the 3D-QSAR results, docking simulation was performed and the most active compound 32 and least active compound 46 was evaluated for their binding interactions in the active site of protease and results were compared.

In the TIM example presented here, none of the designs showed sufficient ligand binding score, so for a new round of designs, it might be beneficial to include ligand binding interactions in the theozyme.

The Binding SPLN was comprised of 171 genes/proteins, including the 33 of the 40 input LAGs (7 of the input LAGs did not have any binding interactions in the binding SPLN but had other interactions in the composite SPLN), 45 essential genes, and 5 genes that either had no known deletions or had representative strains that were not viable.

We synthesized homologated truncated 4′-thioadenosine analogues 3 in which a methylene (CH2) group was inserted in place of the glycosidic bond of a potent and selective A3 adenosine receptor antagonist 2. The analogues were designed to induce maximum binding interaction in the binding site of the A3 adenosine receptor.

The addition to HscA386 of a synthetic peptide with a sequence identical to that of the interdomain linker (LLLDVIPLS) stimulated its ATPase activity and induced widespread NMR chemical shift perturbations indicative of a binding interaction in the trans configuration.

The structure clearly shows the important substrate-binding interactions in the active site.

On closer inspection of the ligand-binding interactions in the X-ray crystal structures of the human EDC and ADR targets, there were often noticeably different residue interaction fingerprints for different ligand chemotypes.

Unlike surface plasmon resonance and other automated instrumentation devoted to the study of protein binding interactions in which the interaction to be quantified is that between a soluble and an immobilized binding partner, the equilibrium binding data determined by kinetic exclusion assays are those obtained for the binding reaction in homogeneous solution.