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Rather, it binds at a site that is known to dynamically regulate binding interactions at the distal groove.
We used single-molecule force spectroscopy to investigate Rho-RNA binding interactions at the Rho utilization site of the λtR1 terminator.
Molecular docking studies identified the orientation and binding interactions at the active site of Akt1 and DNA.
Importantly, the presentation of thus immobilized glycosides makes them available to specific lectin-glycan binding interactions at the polymer-solution interface while, in the absence of specific binding interactions, leads to a reduction in albumin adsorption.
To examine binding interactions at the nicotinic receptor, it has been co-crystallised with the structural homologue acetylcholine binding protein (AChBP; PDB ID 2BYQ), and with an AChBP chimaera (3SQ6) that shares 64% sequence identity with the α7 nACh receptor.
Although the outer binding pocket interactions are very similar for both 15 and 16, compound 16 shows notable differences in the binding interactions at the inner binding pocket of TTR.
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GF was also docked using LigandFit with Nsave 20 to determine the binding interactions at these two sites.
We were able to successfully predict the affinity of peptides between 8 and 11 residues in length by modeling their binding interaction at the C terminus and the three N terminal residues.
The different antiBSA-binding interactions at the surface of the AuNPs caused changes in the surface refractive index, which in turn was transduced into absorbance intensity of the LSPR.
These structures show that larger peptides make extended binding interactions at both the active site and at a distal site.
For instance, we can generalize the degree of dominance of the transcription factor genotype, modeling novel binding interactions at a relative fitness of in individuals heterozygous for the mutant transcription factor (where ).
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