Sentence examples for binding interaction of small from inspiring English sources

Elucidating the binding interaction of small bioactive molecules with DNA provides a structural guideline for designing new drugs with improved selectivity and superior clinical efficacy.

Others are effected by cooperative binding interactions of small peptide elements within regulatory protein polypeptide chains.

Renda, M. et al. Critical DNA binding interactions of the insulator protein CTCF: a small number of zinc fingers mediate strong binding, and a single finger-DNA interaction controls binding at imprinted loci.

Hypochromism suggests the interaction of small molecules with DNA through intercalation, and hyperchromism suggests that the interaction is through groove binding; moreover, hyperchromism is an indication of the breakage of secondary structure of DNA [49].

Similarly to BioNetGen, Simmune focuses on individual binding interactions and a small number of transitions between different states.

Considering that a hydrocarbon and a drug molecule could adopt the same shape, CT helps to identify molecules with similar 3-D orientation of features, e.g., necessary for making binding interactions between a small molecule and protein binding pocket.

Molecular docking provides useful information about drug receptor interactions and is frequently used to predict the binding orientation of small molecule drug candidates to their protein targets in order to predict the affinity and activity of the small molecule [25].

The binding interactions resemble those of known small-molecule inhibitors as opposed to those of substrates and peptidic inhibitors.

We have demonstrated the potential of studying the interactions of small-molecule binding to amyloid fibrils through intrinsic fluorescence and shown that this method is more reliable than assays requiring extrinsic dye labels.

Competitive binding of small guanosine triphosphatases to the IS domain disrupts the autoinhibitory interactions and exposes the IS domain binding site on the surface of the kinase domain.

The cumulative strength of a binding interaction.