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Another exception is in the CDR2α of the LC13 TCR: despite a loop shift of 3.6Å, the Ser hydroxy group moves by 7Å upon binding, interacting with the MHC α2 helix [ 31].
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They all have a core of seven transmembrane α-helices and, after agonist binding, interact with the αβγ G-protein heterotrimers.
Deletion of this tryptophan did not interfere with Nup53 binding to NDC1 or Nup155 (Supplementary Figure S1B), two binding partners interacting with the C-terminal region.
Moreover, Glu446 and Asn172 played essential role in substrate binding by interacting with the −1 subsite of substrates.
Using a two-hybrid screen, we isolated a novel cellular binding partner interacting with the N terminus of HCV nonstructural protein NS5A.
Copper carboxylates, originating from the binding media interacting with the pigment's cation, were observed for both tempera and oil binders [55, 133, 134].
P2.2 formation in a trans-acting ribozyme was exploited to demonstrate that N1 of the guanine at position 1 contributes to GlcN6P binding by interacting with the phosphate of the cofactor.
In addition, structural examination of c.5072C>A/p.Thr1691Lys showed that the alteration significantly disturbed the surface of the binding pocket interacting with the BACH1 phosphorylated peptide [ 28– 30].
BPA has a lower binding affinity, interacting with the α and β estrogen receptors (ER) at 104 times lower potency compared to estradiol [ 16].
In many organisms, polar RNA transport is mediated through RNA binding proteins interacting with the 3'-UTR and controlling localized protein synthesis.
The role of YB-1 in promoting growth of breast cancer cells stems from its original identification as a DNA binding protein, interacting with the regulatory elements of epidermal growth factor receptor (EGFR), HER-2 [ 14] and c-MYC [ 15].
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