Sentence examples for binding inhibitor that interacts from inspiring English sources

This behaviour is again in contrast with that of bortezomib, which acts as a time-dependent slow tight binding inhibitor that interacts covalently with the active site Thr residue, but which displays an equivalent Ki value for the β5 site of 0.56±0.072 nM (mean±S.E.M., n=3).

The idea of PI5P4Kγ as an active PI5P 4-kinase may receive some support from our recent exploitation of a highly specific PI5P4Kγ inhibitor that apparently interacts with the PI5P binding site (J.H.C., M-L.G. et al., unpublished observations).

Covalently linking Sal to a nucleotide or nucleoside analog is expected to yield a bipartite inhibitor that interacts simultaneously with the Sal binding pocket and the active-center i+1 nucleotide binding site, and therefore, that potentially exhibits a very high affinity of binding and a very high potency of inhibition.

This was demonstrated by a hybrid inhibitor that interacts with both the substrate and cofactor binding sites and a recently designed inhibitor 3- 3′,17′β-dihydroxyestra-1′,3′,5′(10′)-trien-16′β-methyl) benzamide which has been crystallized in complex with 17β-HSD1.

ADAR deaminases are RNA-binding proteins that interact directly with their substrates (Klaue et al., 2003).

Another conventional CDK inhibitor that was described to interact with BCRP is purvalanol A [169].

The latter is a heparin binding domain that interacts with HSPGs [14].

The structures show that BCM and its derivatives are nonnucleotide inhibitors that interact with Rho at a pocket adjacent to the ATP and RNA binding sites in the C-terminal half of the protein.

Cornish-Bowden [4] proposed that uncompetitive inhibitors, that is to say inhibitors that interact specifically with an intermediate on an enzyme reaction pathway, are especially powerful inhibitors.

This signature includes the GTPBP4 gene coding for a GTP-binding protein that interacts with p53.

The tail domains of myosin XV have several binding sites that interact with other proteins.