Sentence examples for binding induces conformational changes from inspiring English sources
Through interactions of co-evolving residues, protein substrate binding induces conformational changes of PKs that are essential for phosphoryl transfer [50] [52].
Significant quenching (approximately16% decrease) was found in the Alexa-488 fluorescence spectra of Alexa-488 labeled LigBCen2RW1073C, a LigBCen2 mutant lacking its sole tryptophan, when GBD was added with dose dependence confirming that GBD binding induces conformational changes in LigBCen2R (Figure 1D).
Furthermore, cofactor binding induces conformational changes that in turn could affect oligomerization [ 11, 13].
ATP binding induces conformational changes in the NBD subdomains, promotes interdomain docking between the SBD and NBD, and promotes high on off rates for the substrate.
Taken together, our results indicate that nucleotide binding induces conformational changes within ORC that are propagated throughout the entire complex to stabilize a specific structural state.
Because these residues are relatively well removed from the lactose-binding site, it appears that lactose binding induces conformational changes, however minor, in other regions of the folded protein.
The X-ray crystal structure of the DOT1L EPZ-5676 complex (PDB code: 4HRA) clearly indicated that (1) EPZ-5676 occupied the cofactor binding pocket and (2) ligand binding induced conformational changes in the protein.
As W7 binding induced conformational changes in cNTnC·Ca2+ that were similar (as monitored by NMR) to those induced by the binding of Sp (9, 10), we investigate the assumption that the distance restraints used to define the protein conformation can be reused from the study defining the structure of the cNTnC·Ca2+·Sp complex.
The binding then induces conformational changes of the gp120, which allows the gp120 to interact with a cellular surface chemokine receptor, termed coreceptor [1].
