Sentence examples for binding induces allosteric changes from inspiring English sources
Ligand binding induces allosteric changes in the receptor conformation, leading to the activation of intracellular signaling pathways, including the Ras-MAPK, PI3K-PKB-mTOR and small GTPases (e.g. Rho, Rac) pathways ("outside-in" signaling) [2].
This modification induces allosteric changes in Keap1 that prevent the marking of Nrf2 for proteasomal degradation.
Remarkably, cardiolipin binding induces allosteric modifications in cytochrome c tertiary structure switching cytochrome c function(s) from mitochondrial respiration to apoptosis.
Interestingly, receptor binding to coactivator can induce allosteric changes in coactivators enhancing the recruitment of other coactivators, consequently increasing receptor-dependent transcription.
Alternatively, the mutated residue Val-145 might be critical for receptor activation by inducing allosteric changes in the receptor upon binding.
Pseudokinases have been observed to perform important functions in other systems, typically through inducing allosteric changes in other interacting partners (e.g. [ 30, 31]; reviewed in [ 32- 34]).
Differences in patterns of miRNA-target RNA base pairing can induce allosteric changes in the RISC complex, potentially leading to different AGO activities.
Bettridge, J., Na, C. H., Pandey, A. & Desiderio, S. H3K4me3 induces allosteric conformational changes in the DNA-binding and catalytic regions of the V(D J recombinase.
Similarly, Dantrolene-induced allosteric changes in the myoplasmic region of RyR1 may affect CaV1.1 in such a way that causes a depolarizing shift in L-type current activation.
