Sentence examples for binding induced conformational changes from inspiring English sources
Theophylline binding induced conformational changes in the riboswitch, thereby activating it and resulting in an efficient csrA translation (i.e., autoaggregation did not occur).
The X-ray crystal structure of the DOT1L EPZ-5676 complex (PDB code: 4HRA) clearly indicated that (1) EPZ-5676 occupied the cofactor binding pocket and (2) ligand binding induced conformational changes in the protein.
As W7 binding induced conformational changes in cNTnC·Ca2+ that were similar (as monitored by NMR) to those induced by the binding of Sp (9, 10), we investigate the assumption that the distance restraints used to define the protein conformation can be reused from the study defining the structure of the cNTnC·Ca2+·Sp complex.
Binding induced conformational changes in the RNA polynucleotides were revealed from circular dichroism data.
The chemical environment can change due to direct interaction with the substrate or due to substrate binding induced conformational changes, even minor ones.
These structural data indicate that Ca2+ binding induces conformational changes that generate the active site cleft.
MgATP binding induces conformational changes and protein-protein association.
Through interactions of co-evolving residues, protein substrate binding induces conformational changes of PKs that are essential for phosphoryl transfer [50] [52].
Significant quenching (approximately16% decrease) was found in the Alexa-488 fluorescence spectra of Alexa-488 labeled LigBCen2RW1073C, a LigBCen2 mutant lacking its sole tryptophan, when GBD was added with dose dependence confirming that GBD binding induces conformational changes in LigBCen2R (Figure 1D).
Furthermore, cofactor binding induces conformational changes that in turn could affect oligomerization [ 11, 13].
ATP binding induces conformational changes in the NBD subdomains, promotes interdomain docking between the SBD and NBD, and promotes high on off rates for the substrate.
