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Thus, we designed an FMRI study aimed at investigating the neural correlates of both passive and active binding in working memory in schizophrenia.
The deficits were mainly predicted by altered executive function (i.e., updating) for past periods, as well as by general semantic and feature binding in working memory for the future period, independently of the injury characteristics.
Moreover, regression analyses mainly show that increase in age-related deficit with level of specificity of AM is largely mediated by performance on executive functions (updating and inhibition) and to a lesser extent feature binding in working memory.
We used a new task composed of four embedded verbal autobiographical fluencies (VAF) – from low to highest specificity levels – exploring lifetime periods, general events, specific events, and details, plus tasks exploring free recall of episodic AM and updating, shifting, inhibition, and feature binding in working memory.
Further, it has been proposed that arousal levels, irrespective of emotional mood valence, may be critical for feature binding in working memory [4] and long-term memory for word lists [5].
In the current study we set out to investigate the involvement of the MTL in binding in working memory by contrasting directly whether the hippocampal activation depends on the presence of a spatial component, or that the MTL is implicated in the binding non-overlapping neural representations in general.
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In all, our results clearly show that different binding processes in working memory evoke different patterns of activation in brain activation.
Using a hybrid fMRI design, that allows separate analysis of transient and sustained components, an n-back task and an experimental group of 13 hearing native signers, with experience of Swedish Sign Language and Swedish since birth, we investigated binding of lexical signs and words in working memory.
Therefore, the number of objects in working memory is limited.
This dissociation is apparent in working memory function too.
Healthy aging is characterized by declines in working memory and new episodic memory performance with relative sparing of semantic memory, recognition memory, and priming.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com