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By contrast, the signal for MYOD binding in the vicinity of PRI 2 was virtually undetectable.
Our analyses do indicate, however, that the most prevalent transcriptionally functional mechanisms involve binding in the vicinity of the TSS.
Possibly due to this, Tsankov et al. and Lolas et al. did not detect BRA binding in the vicinity of many important mesodermal loci (Table 1).
Second, the intron retention appeared to be also enhanced by RBM10 binding in the vicinity of its splice sites, especially the binding near 5′ splice sites (Fig 5B).
However, shifts were dependent on initial rimantadine binding in the vicinity of Leu20, supporting this as the primary adamantane interaction surface.
Thus, the increased retention of C/EBPα binding in the vicinity of highly upregulated genes, originates from increased retention of the binding sites that overlap with PPARγ binding.
Similar(45)
Such behavior is robust across all cancer SM callsets, including those with lower baseline levels of protein-binding in the vicinity of breakpoints, such as the ETSwt/CHD1del subset of Prostate-Baca and also Head&Neck-Stransky.
The latter equality defines k2, a pseudo-first order reaction rate constant, as k 1 ′ [ B ]. Here, [B] is the concentration of the B DNA binding site in the vicinity of the A binding site.
To accomplish this, we searched two datasets of experimentally supported transcription factor binding events for Oct4, Nanog, and Sox2 binding sites in the vicinity of the TUs: chromatin immunoprecipitation paired-end diTags (ChIP-PET) [ 3] and ChIP-sequencing by Solexa technology [H. H. Ng et al., unpublished].
Regardless of method, we find that there is a significantly increased retention as well as turn-over of PPARγ binding sites in the vicinity of genes upregulated during adipogenesis compared with binding sites more distant from such genes.
Up-regulation of miR-20b, a member of the miR-106a cluster located on X chromosome, was also consistently observed in the high c-Myc state and seven putative binding sites in the vicinity of the miR-106a cluster were also identified even though no direct binding between c-Myc and these binding sites has been reported [33].
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binding in the monkey
binding in the absence
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