Sentence examples for binding in the small from inspiring English sources

The fixed conformation of a planar substrate would assist binding in the small rigid active site cavity.

Interestingly, the addition of BoNT/A holotoxin with HA-C did not enhance the time of BoNT/A appearance or binding in the small intestines to that seen in BoNT/A complex-treated mice (Fig. 5).

The three residues are separate in the primary structure but their common participation in binding the small Zn II) ion define their spatial proximity in the tertiary structure of the transporter.

IBP1, identified in this mixture, is most likely playing a role in the binding between the small ribosomal subunit and GLV IRES.

Similar to the ZipA/FtsZ contacts, the driving force in the binding of the small molecule ligands to ZipA is achieved through hydrophobic interactions.

In these trials, binding of the small molecule kinetic stabilizer drug tafamidis or diflunisal dramatically slows the progression of TTR polyneuropathy, as measured by neurologic impairment scores, quality of life assessments, and other metrics.

Steric hindrance has also been implicated in the reduced binding of the small G protein ras to its guanine nucleotide exchange factor Cdc25 upon ADP-ribosylation of ras at Arg41 (Ganesan et al. 1999b), and in altered DNA recognition by E. coli RNA polymerase upon ADP-ribosylation at Arg265 (Depping et al. 2005; Westblade et al. 2008).

Because the trend obviously indicates an advantage in binding efficiency for the small molecules, which is both attractive and expected in drug design, the LE BEII) approach has become more and more popular in academia and pharma drug design.

The residues forming the substrate-binding pocket are located in the small lobe (residue F212) and on or near the variable loop (residues I167, S168, N173, and Q178).

CS6-binding sulfatide was present in the small intestine of species susceptible to CS6-mediated infection, e.g. humans and rabbits, but lacking in species not affected by CS6 ETEC, e.g. mice.

The specific GK residues that mediate binding with GKRP are located in the small domain and hinge region in the folded protein and partly overlap with the glucose-binding domain [ 10].