Sentence examples for binding in the second from inspiring English sources

Inhibitor binding in the second active site requires much higher concentrations than binding in the first active site, which gives rise to the phenomenon of substrate-selective inhibition.

Their status as relatively weak, rapidly reversible COX inhibitors derives from the fact that they have to bind to both subunits of COX-2 (and presumably COX-1) to inhibit productive binding of AA and that binding in the second subunit is competitive with AA.

These observations indicate that although all of the inhibitors induce conformational changes in the second subunit following binding in the first subunit, there are differences in the nature of the conformational changes induced as judged by the differential effects on 2-AG and AA binding in the second subunit.

It effectively diversifies receptor function and generates species-specific isoforms by introducing variations in the Cys-loop that are involved in receptor assembly, in loops E and B. These variations contribute to ligand binding in the second transmembrane domain, which forms the ion channel between TM2 and TM3, that are important in coupling agonist binding to ion channel gating [ 40, 41].

We would like to emphasize that this "driving" energy is gained from substrate binding in the first half of the transition but is immediately released in the second half of the same transition.

These responses seem to play right into the hands of the ideal utilitarian: the promise is more binding in the first case because of the greater value at stake and in the second case because the expectation and the disappointment are greater, all of which are goods of the sort that the ideal utilitarian claims we need to balance in deciding what we ought all things considered to do.

Here, we investigated BA transport and Myrcludex B binding in the first Slc10a1-knockout mouse model (Slc10a1 encodes NTCP).

Strikingly, 765 of the 2,610 regions enriched for NKX2-5 binding (29.31%) also were identified by MEIS binding in the first branchial arches.

Therefore, we recently generated a variety of GrB mutants, which showed a reduced PI-9-inhibitor binding in the first experimental studies.

Further work is required to resolve the functional basis for this, but a potential mechanism involves modulation of a novel regulatory element involving CTCF binding in the first intron of ZFP57.

MALT1 requires its DD and Ig-like domains to bind BCL10, while TRAF6 is recruited to TRAF6 binding sites in the second Ig-like domain (T6-Ig) and the C-terminus (T6-C) of MALT1 (Fig 1A) [26].