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This illustrates a possibility to use dPORE-miRNA for the detailed exploration of SNP-influenced TF binding in the regulatory regions of miRNA genes.
dPORE-miRNA allows for the detailed exploration of SNP-influenced TF binding in the regulatory regions of these miRNA genes, which could unlock valuable information on the expression levels of this important cancer gene.
Recent NMR investigations of the binding of cAMP to the apo form of RIα 98 379) provided further novel information on the allosteric communication of cAMP binding in the regulatory subunit of PKA, with the αC A and αC' A helices (residues 225 256) playing essential structural roles in A B intersite communication [9].
Therefore, the mechanism that couples calcium binding in the regulatory domain to substrate transport in the carrier domain has not been resolved.
We also confirm the findings from array CGH studies that NFKBIZ and the oncogene PIM2 are elevated in ABC lymphoma (Tirado et al. 2012), but with the added information that STAT3 shows elevated levels of binding in the regulatory domains of these genes.
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The binding potential score calculated by GOMER reflects all of the potential binding sites in the regulatory region.
To identify the presence of DSX binding sites in the regulatory regions of Drosophila genes, we used the known DSX binding site (ACAAWGT) [ 46].
Each binding site in the regulatory region ρi is bound if the matching gene product is present (i.e. if xik⊂R t)).
The expression of MAG in our animal models is correlated with TH level suggesting that the presence of a TR binding site in the regulatory region of the gene is genuine.
The ProteinDNAInteraction class contains specific attributes that reflect the unique aspects of protein-DNA interactions, such as protein (TF) binding sites in the regulatory regions of the target genes.
The interaction of the cis-regulatory elements of a gene with transcription factors (TF) largely determined transcription event, therefore, an assessment of the putative TF binding sites in the regulatory region of the gene under analysis yields important information on this gene's regulation.
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