Sentence examples for binding in the reference from inspiring English sources
Assumption 3 (on the specific binding in the reference tissue, k 3r): Specific binding of radioligand is negligible in the reference tissue (k 3r = 0).
Violations of model assumptions such as activation-induced changes in regional blood flow or specific binding in the reference tissue have negligible effects on lp-ntPET performance.
Yet, it should be mentioned that both plasma input-derived DVR 1 and SRTM-based BPND estimates will be negatively biased by the presence of specific binding in the reference region (pons), as discussed below.
Non-specific binding in the reference cell was subtracted.
If this latter assumption is violated, independent of the presence of specific binding in the reference region, the DVR estimates obtained by SRTM will be biased [ 20].
Additional file 1: Figures showing H3K9me3 binding in the MIPS reference with alignments of RRes and MIPs reference to highlight where centromeric sequence was present in the Connolly et al. study.
The lower nonspecific binding in the extracted reference voxels may provide the reason why the cerebellar cortical reference tissue constantly gave slightly negative ( {BP}_{mathsf{ND}}^{ast } ) values in the "nonbinding" cortical gray matter regions without tau accumulation (Fig. 4; −0.14 ± 0.05 in HCs and −0.13 ± 0.03 in ADs).
In 3P++ analysis we assume that k 3r = 0, that is, specific binding is negligible in the reference tissue.
Radiotracer uptake is measured after binding in the cortex and reference region reaches a steady state 40 50 minutes after injection.
As pointed out by Reviewer #2, the number listed for the hydrogen bond enthalpy seems to be judiciously picked to yield agreement with the calculated binding energy (the reference pointed to in the manuscript lists a slightly different value) and moreover hydrogen bonding energies are known to be rapidly varying functions of bonding geometry.
a) Entries which made up the training sets for each of the MM and QM methods used to estimate the free energy of binding; b) the reference PDB structure used in the modelling the protein-ligand complex where an experimentally determined X-ray structure was not available.
