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Elmenhorst, D. et al. Sleep deprivation increases A1 adenosine receptor binding in the human brain: a positron emission tomography study.
Volkow ND, Fowler JS, Wang GJ, Dewey SL, Schlyer D, MacGregor R et al. Reproducibility of repeated measures of carbon-11-raclopride binding in the human brain.
We were able to demonstrate SERT binding in the human hypothalamus in vivo.
A reference tissue model showed positive binding potential values, indicating the existence of specific binding in the human gray matter.
This study is the first to demonstrate in vivo SERT binding in the human hypothalamus using [123I]FP-CIT SPECT.
Previous SPECT studies have reported SERT binding in the human thalamus/hypothalamus region, hypothalamic/midbrain area, or diencephalon [18, 22, 36], and one study examined human hypothalamic SERT binding using PET imaging and [11C]DASB [11C]DASB
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Moreover, a similar role of the CRD domain in carbohydrate-binding in the human mechanosensor polycystin seems rather redundant, since it also carries a number of PKD domains, which already fulfill this function [32].
Specifically, we used the JASPAR database of transcription factor binding motifs [29] to predict binding sites in the human and chimpanzee versions of each HAR sequence.
To compare the selected sets of the putative binding sites, we computationally predicted all binding sites in the human genome using our affinity data (Additional file 5).
Thus, the ChIP assay shows that endogenous Tcf-4 and β-catenin proteins bind to the Tcf/Lef binding site in the human OPN promoter.
The search for cohesin binding sites in the human genome showed overlap with CCCTC binding factor (CTCF) sites.
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