Sentence examples for binding in the first from inspiring English sources

The kcat(H2O2) values are dependent on the electron deficiency of the metal site as it controls the peroxide binding in the first step of the dismutation process.

We would like to emphasize that this "driving" energy is gained from substrate binding in the first half of the transition but is immediately released in the second half of the same transition.

These responses seem to play right into the hands of the ideal utilitarian: the promise is more binding in the first case because of the greater value at stake and in the second case because the expectation and the disappointment are greater, all of which are goods of the sort that the ideal utilitarian claims we need to balance in deciding what we ought all things considered to do.

Here, we investigated BA transport and Myrcludex B binding in the first Slc10a1-knockout mouse model (Slc10a1 encodes NTCP).

Strikingly, 765 of the 2,610 regions enriched for NKX2-5 binding (29.31%) also were identified by MEIS binding in the first branchial arches.

Inhibitor binding in the second active site requires much higher concentrations than binding in the first active site, which gives rise to the phenomenon of substrate-selective inhibition.

It effectively diversifies receptor function and generates species-specific isoforms by introducing variations in the Cys-loop that are involved in receptor assembly, in loops E and B. These variations contribute to ligand binding in the second transmembrane domain, which forms the ion channel between TM2 and TM3, that are important in coupling agonist binding to ion channel gating [ 40, 41].

Their status as relatively weak, rapidly reversible COX inhibitors derives from the fact that they have to bind to both subunits of COX-2 (and presumably COX-1) to inhibit productive binding of AA and that binding in the second subunit is competitive with AA.

The E2 binding site in the first Zn-binding loop, and the second Zn-binding site that interacts with the Ile36-patch of Ub are conserved.

Target-ligand interaction energy (Einter) increases with increasing number of cycles finding strong binding sites in the first few cycles, before the final, saturation region.

Had we claimed overrepresentation of binding sites in the first 2000 bp, discovery bias would have been a valid concern.