Sentence examples for binding in the extracellular from inspiring English sources

One element of the allosteric mechanism that produces the conformational changes through propagation of local perturbations, rather than large rigid body motions, is the effect of ligand binding in the extracellular vestibule of LeuT, termed the S2 binding site [29].

Thus one cross-talk between the Wnt and the EGF pathways is at the level of ligand binding in the extracellular space and may regulate reciprocal activities during embryogenesis.

These latter two inhibitors also target cysteine protease C14 by direct binding in the extracellular compartment [ 13].

Integrins are large complex molecules, where ligand binding in the extracellular head domains depends on divalent cations which can act to stimulate (usually Mg2+) or inhibit (usually Ca2+) ligand binding.

In the Pgp conformations that approached the fully opened outward ADP-Vi transition state, ligand binding in the extracellular half of the TMDs was not favored, with preferred docking found in the cytoplasmic half of the membrane regions.

This may be mechanistically important, because the destabilization of ligand binding in the extracellular half of the drug binding site, coupled with denied access to ligand binding on the cytoplasmic side, would effectively force release of the ligand to the extracellular space.

The functional significance of secreting sugar-binding proteins: these sugar binding domains in the extracellular proteins are likely to provide a means for associating with the sugar moieties in extracellular biopolymers such as peptidoglycans and other glycans present in surface capsules and gums.

Shed ectodomain can also compete with the membrane-bound syndecan-1 for ligand binding, and it can sequester the HS binding factors in the extracellular matrix and thereby modulate their biological functions [ 84].

In this report, we used a receptor binding domain sequence-based prediction method to identify four putative binding sites in the extracellular domain of WAK1, in which cationic amino acids were selected for substitution by site-directed mutagenesis.

Cetuximab is modeled as a monovalent binder of EGFR to focus on a more straightforward comparison between drugs that compete with single ligand or ATP binding events in the extracellular or intracellular compartments, respectively, but the slightly enhanced binding affinity observed for the bivalent full-length antibody was used in model parameterization.

suggested a possible allosteric chloride binding site in the extracellular domain of metabotropic glutamate receptors (mGluRs) by comparison with a similar site found in atrial natriuretic peptide receptor.