In the previous version of model, it was assumed that glucose molecules equal to size of CBM only are required on surface and unblocked for binding, however in the current model whole length of enzyme was considered (except linker, because it is flexible and is compressed during movement) (Wang et al. 2012).
Previous studies have shown that hTLR2 can accommodate two ester bound lipid chains [31] and hTLR10 was found to possess amide bound lipid binding chains in the current study, which indicates that the tri-acylated (Pam3CSK4) lipopeptides act as ligand molecules.
The inclusion of full-length IFNα/βBP, or, even better, a mutagenized version of the protein lacking IFN-binding activity, in the current smallpox vaccines may induce better anti-IFNα/βBP response and enhance their protective effect.
The binding data generated in the current study (RXRα and RARα) were compared with the binding data of PXR, LXR, FXR, and PPARα.
Although these studies have identified transcription factors that lie upstream of IRF6 during craniofacial development, the downstream targets of IRF6 remain uncharacterized; in this context, delineation of the consensus IRF6 binding site detailed in the current study will facilitate the identification of putative transcriptional targets of IRF6.
The metal-binding cupins identified in the current study are a potential example of the evolutionary transition of an ancestrally sugar-binding double-stranded β-helix domain to an amino acid/peptide modifying enzyme.
A total of 70 samples positive by IHC, 33 positive by estrogen binding assay, 43 negative by IHC and 20 negative by estrogen binding assay were included in the current study (Tables 1, 2, 3 and 4 respectively).
The initial structure of LFABP complexes with two ANS molecules was obtained from the molecular docking results [3]; only one of three representative poses of ANS at the high affinity binding site was used in the current study.
The specific binding sites are identified in the current structure.
The finding of sdc-3 binding and presenting CXCL1 in the current study is in agreement with our previous study [ 33].
