Sentence examples for binding in the conserved from inspiring English sources

Virus neutralization is not only effected by antibodies that bind to the receptor binding region, but also by antibodies binding in the conserved HA2 region, that, for instance, block the pH-dependent conformational change required for membrane fusion and infectivity [38].

Previous studies have shown that Ca2+ binding in the conserved RTX domain is coupled to the folding and activation of the protease domain, putatively providing a means of protease regulation during biosynthesis and secretion.

Primers 27F (5′-agagtttgatcctggctcag-3′) and 1100R (5′-gggttgcgctcgttg-3′), binding in the conserved region, were used at 0.4 mM concentration with 200 mM dNTP and 1 U Taq polymerase (NEB, Ipswich, MD, USA).

Our results point to a classic allosteric regulation mechanism where either phosphorylation in the activation loop or TPX2 binding in the conserved remote hydrophobic groove shifts the equilibrium far towards the active state.

In the case of degraded herbarium materials, ITS-1 and ITS-2 were amplified separately using in addition two internal primers, ITS-C(R) and ITS-D(F) binding in the conserved 5.8S rDNA [ 73].

Recently, ES6/7S have been implicated in binding of the conserved translation initiation factor eIF3 based on superposition with a mammalian 43S complex (Hashem et al., 2013).

We therefore speculate that the positively charged surface of kurtoxin is an important determinant of its binding to the conserved negative domain in Cav3 (T-type) Ca2+ channels.

Since potential HNF4α binding sites were detected in the conserved module A (as well as in the -295/-265 module), the liver-specific stimulation of HL promoter activity may well be mediated by HNF4α.

The Apaf-1 residues involved in cytochrome c binding in the PatchDock' model are conserved among the vertebrates, in agreement with the common apoptosome assembly pathway and conserved cytochrome c residues (red arrows in Fig.  10).

This association is fundamentally based on the similarity in ligand binding sites depicted in Figure 2A, where the conserved helix-turn-helix motif simply provides secondary support of a PrgI and Bcl-2 functional link.

The constellation of Bub3 residues implicated in MELTP binding is perfectly conserved in the nucleoporin Rae1, suggesting that Rae1 might also be implicated in phosphopeptide binding.